Tuesday, February 25, 2014


-"Huntington's Disease: MedlinePlus." U.S National Library of Medicine. U.S. National Library of Medicine, n.d. Web. 18 Feb. 2014.<http://www.nlm.nih.gov/medlineplus/huntingtonsdisease.html>.



-"Huntington's Disease Symptoms, Causes, and Treatment - MedicineNet."MedicineNet. N.p., n.d. Web. 19 Feb. 2014. <http://www.medicinenet.com/huntington_disease/article.htm>.

Board, A.D.A.M. Editorial. "Huntington's Disease." Huntington Disease. U.S. National Library of Medicine, 28 May 2013. Web. 22 Feb. 2014. <http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001775/>.

"NINDS Huntington's Disease Information Page." Huntington's Disease Information Page: National Institute of Neurological Disorders and Stroke (NINDS). Office of Communications and Public Liaison National Institute of Neurological Disorders and Stroke National Institutes of Health, 5 Dec. 2013. Web. 22 Feb. 2014. <http://www.ninds.nih.gov/disorders/huntington/huntington.htm>.

Wednesday, February 19, 2014

The disease is not from sex linked causes, but it can be passed down genetically after the autosomal mutation occurs. 

That is The Huntington's Disease karyotype. As you can see chromosome four is affected. 

There is a 50% chance of offspring being born with the chomosomal mutation.  50% of the offspring are homozygous and the other 50% are heterozygous. This punnett square applies to a family with one parent being affected and the other not being affected. Huntington's disease is a dominant trait. 

I came to the decision that I want to know more about the disease that has been tormenting my family, and what I found is rather frightening. Huntington's Disease is a dominant trait that has autosomal inheritance. It affects chromosome four with dynamic mutation(There is unnecessary copying of the chromosomes protein). The offspring who have the mutated copy of the gene will have the disease. With this type of inheritance pattern, each offspring of an affected parent has a 50% risk of inheriting the mutated allele and therefore they'll be affected by this disorder. The thing that bothers me the most about this is that there is a possibility that either my siblings or I carry Huntington's Disease. 

B. Lewis
6/14/11






Update #2: The symptoms have set in completely and there's not much more to say. Our daily routine  remains the same. The only new thing is that we have to constantly be aware of his safety. He is constantly confused and disoriented, and he has loss of memory and judgment. At this point it's like I lost my father, and he doesn't have much more time left anyways.

5/14/11
It's the first update on how my father is doing. The symptoms have almost set in fully and now it's up to time. Yesterday he continued to show his symptoms, he's not himself anymore.  It doesn't make physical life that much more difficult, but its emotionally destructive. The only difference physically is that we have to treat him as a young child. He cant do anything himself anymore. Our days are very simple. He'll wake up and eat breakfast like every other person. He spends most of his time sitting around, but on good days he'll try to entertain himself, or even have a conversation with me. He usually eats lunch, but that depends on how he's feeling. After that my family and I will try to spend as much time with him as possible. He eats an early dinner and goes to bed soon after. About every other week he goes in for a checkup to see how he's doing and to make sure he's staying as healthy as possible. My family and I adjusted to our change quickly and love our father as much as ever.

More Later, B. Lewis
9/14/10
The past week has been more than I can handle. Last month I started noticing that my father was acting strange. He wasn't himself. It was basic things like moodiness and restlessness. I didn't think that much of it, but then it started to get more serious. Day after day he had hallucinations and temporary psychosis! At this point I was gravely concerned and I knew it was time to see a professional. We discovered that he has been diagnost with Huntington's Disease. I no longer know what to expect and think, so I'm writing this blog to keep my friends and family up-to-date.

More Later, B. Lewis
1/14/10